Local field potentials (LFPs)-based adaptive deep brain stimulation (aDBS) is a safe, tolerable, and effective treatment strategy for managing clinical fluctuations associated with Parkinson disease(PD), according to findings from a small study published in Neurology.
A total of 11 patients with rigid-akinetic advanced PD were included in this study, all of whom had undergone surgical intervention for implantation of a DBS electrode in the subthalamic nucleus. The experiment, which took place following DBS surgery and prior to connection of the leads to the subcutaneous pulse generator, consisted of 2 sessions conducted with a portable aDBS prototype device for 8 hours per session, per day. On day 1, each patient took their daily medication, and on day 2 each patient received subthalamic nucleus aDBS by means of LFPs beta band power.
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